By Maureen Salamon
Comparing the DNA of more than 2,300 patients afflicted with migraines without aura — the most common type — with 4,580 people in the general population, German and Dutch scientists spotted two gene variants associated with that migraine form. The research, authored by Arn van den Maagdenberg of Leiden University Medical Centre in the Netherlands, builds on a U.S. study released last year identifying three genes linked to migraines that suggested those inheriting any one of those genes had a 10 percent to 15 percent greater risk for the condition.
“Migraines are under-treated, under-recognized and under-diagnosed, especially with common migraines that don’t have any of the dramatic symptoms,” said Dr. Gayatri Devi, an attending neurologist at Lenox Hill Hospital in New York City. “A lot of times, people feel it’s their fault or that stress causes them . . . it’s nice to know there are genetic basis for illnesses and it’s not all in your head.”
The study is published online June 10 in the journal Nature Genetics.
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